dopaminergicneurons相关论文
Parkinson\'s disease(PD)is a multifactorial disorder of the nervous system where a progressive loss of dopaminergic ne......
Astrocytes protect neurons by modulating neuronal function and survival.Astrocytes support neurons in several ways.They ......
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson&#
Parkinson\'s disease is the most common movement disorder worldwide, affecting over 6 million people. It is an age-rel......
The neurotrophic signaling of glial cell line-derived neurotrophic factor (GDNF) with its canonical receptor, the recept......
Acrylamide can form in foods during cooking process and cause multiple adverse effects.However,the neurotoxicity and mec......
Increased synthesis and secretion of proNGF in the activated microglial cells and related regulation
It is well known that the activated glial cells generate a variety of neurochemical factors and involved in modulation o......
Objective:Accumulating evidence shows that α-synuclein (α-Syn) plays a key rolein the pathogenesis of Parkinsons disea......
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Objective To investigate the relationship between TLR3-TRIF signaling pathway and microglial activation as well as polar......
The Kv7/KCNQ channel blocker XE991 protects nigral dopaminergic neurons in the 6-hydroxydopamine rat
The excitability of dopaminergic neurons in the substantia nigra pars compacta(SNc)that supply the striatum with dopamin......
Aim: Calcium/calmodulin-dependent protein kinase Ⅱ nuclear isoform, CaMKⅡδ3is highly expressed in the domapminergic n......
Protective effects of Ethyl acetate extract from chroogomphus on the degeneration of dopaminergic ne
Objective: To investigate the protective effects of different concentration of Ethyl Acetate (EA) extract from Chroogomp......
Parkinsons disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the ......
Synaptic vesicle exocytosis-based neurotransmission and the subsequent membrane retrieval through endocytosis are crucia......
Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor(GHS-R).Through affecting the electrical prop......
The protective effects of icariin on Lipopolysaccharide-Induced dopaminergic neuronal damage in rats
Objective: To investigate the protective effects of icariin (ICA), one of active components of epimedium, on Lipopolysac......
A comprehensive study on long-term injury to nigral dopaminergic neurons following intracerebroventr
Parkinson s disease (PD) is characterized by selective and progressive degeneration of dopaminergic neurons in the subst......
Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural pro
Loss of midbrain dopaminergic (DA) neurons is a pathological feature of Parkinson s disease (PD).Recent advances in the ......
Effects of glial cell line-derived neurotrophic factor on microRNA expression in a 6-hydroxydopamine
Parkinsons disease is characterized by the irreversible and selective loss of nigrostriatal dopaminergic neurons.Glial c......
Objectives: To investigate whether overexpression of Nurr1 (nuclear receptor-related factor 1) enhances the vulnerabilit......
Direct conversion of human fibroblasts into dopaminergic neuron-like cells using small molecules and
Background:Generation of neurons is essential in cell replacement therapy for neurodegenerative disorders like Parkinson......
Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function, and also regulate p......
For decades, clinicians have developed medications and therapies to alleviate the symptoms of Parkinson’s disease, but ......
目的 利用大鼠脑室内注射低剂量脂多糖(lipopolysaccharide,LPS)(10μg)诱导全脑炎症,长时间观察大鼠行为学、黑质部位小胶质细胞......
目的 探讨TFP5对1-甲基-4-苯基-1,2,3,6-四氢吡啶(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,MPTP)诱导的小鼠帕金森病(Parki......
BACKGROUND: Previous researches suggested that expression level of calbindin D28K mRNA decreased in substantia nigra (SN......
Transplantation of primary cultured embryonic mesencephalic neural precursor cells for treating Park
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Intrastriatal glial cell line-derived neurotrophic factors for protecting dopaminergic neurons in th
BACKGROUND: Substantia nigra is deep in position and limited in range, the glial cell line-derived neurotrophic factor (......
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Panax notoginseng saponins influence on transplantation of neural stem cell-derived dopaminergic neu
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Effect of rifampicin pre- and post-treatment on rotenone-induced dopaminergic neuronal apoptosis and
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The goal of this study was to increase the dopamine content and reduce dopaminergic metab-olites in the brain of Parkins......
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We previously reported that intranasal insulin protects substantia nigra dopaminergic neurons against6-hydroxydopamine n......
BACKGROUND: To date, many 6-hydroxydopamine (6-OHDA)-lesioned rat models have been established by injecting 6-OHDA into ......
Protective effect of bone marrow-derived mesenchymal stem cells on dopaminergic neurons against 1-me
BACKGROUND: To date, the use of bone marrow-derived mesenchymal stem cells (MSCs) for the treatment of Parkinson's disea......
Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminer
The over-expression of α-synuclein is a major factor in the death of dopaminergic neurons in a methamphetamine-induced ......
目的 观察脑室内注射脂多糖(lipopolysaccharide,LPS)引起的脑内炎症对大鼠黑质多巴胺能神经元的慢性毒性作用,探讨星形胶质细胞是......
Intrastriatal glial cell line-derived neurotrophic factors for protecting dopaminergic neurons in th
BACKGROUND: Substantia nigra is deep in position and limited in range, the glial cell line-derived neurotrophic factor (......
